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Gold in PDB 5e5f: X-Ray Structure of the Complex Between Rnase A and Compound 4-PF6 ([(PPH3)Au(Mi-Pbi)Pt(Me)(Dmso)][PF6]), the Heterobimetallic Derivative Obtained in the Reaction Between the Organometallic Compound [Pt(Pbi)(Me)(Dmso)], Pbi=2-(2'-Pyridil)Benzimidazole (Compound 3) and the Gold(I) Compound [Au(PH3P)][PF6]

Enzymatic activity of X-Ray Structure of the Complex Between Rnase A and Compound 4-PF6 ([(PPH3)Au(Mi-Pbi)Pt(Me)(Dmso)][PF6]), the Heterobimetallic Derivative Obtained in the Reaction Between the Organometallic Compound [Pt(Pbi)(Me)(Dmso)], Pbi=2-(2'-Pyridil)Benzimidazole (Compound 3) and the Gold(I) Compound [Au(PH3P)][PF6]

All present enzymatic activity of X-Ray Structure of the Complex Between Rnase A and Compound 4-PF6 ([(PPH3)Au(Mi-Pbi)Pt(Me)(Dmso)][PF6]), the Heterobimetallic Derivative Obtained in the Reaction Between the Organometallic Compound [Pt(Pbi)(Me)(Dmso)], Pbi=2-(2'-Pyridil)Benzimidazole (Compound 3) and the Gold(I) Compound [Au(PH3P)][PF6]:
3.1.27.5;

Protein crystallography data

The structure of X-Ray Structure of the Complex Between Rnase A and Compound 4-PF6 ([(PPH3)Au(Mi-Pbi)Pt(Me)(Dmso)][PF6]), the Heterobimetallic Derivative Obtained in the Reaction Between the Organometallic Compound [Pt(Pbi)(Me)(Dmso)], Pbi=2-(2'-Pyridil)Benzimidazole (Compound 3) and the Gold(I) Compound [Au(PH3P)][PF6], PDB code: 5e5f was solved by A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 69.00 / 1.68
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 99.487, 31.215, 69.012, 90.00, 90.69, 90.00
R / Rfree (%) 18.3 / 23.4

Gold Binding Sites:

The binding sites of Gold atom in the X-Ray Structure of the Complex Between Rnase A and Compound 4-PF6 ([(PPH3)Au(Mi-Pbi)Pt(Me)(Dmso)][PF6]), the Heterobimetallic Derivative Obtained in the Reaction Between the Organometallic Compound [Pt(Pbi)(Me)(Dmso)], Pbi=2-(2'-Pyridil)Benzimidazole (Compound 3) and the Gold(I) Compound [Au(PH3P)][PF6] (pdb code 5e5f). This binding sites where shown within 5.0 Angstroms radius around Gold atom.
In total only one binding site of Gold was determined in the X-Ray Structure of the Complex Between Rnase A and Compound 4-PF6 ([(PPH3)Au(Mi-Pbi)Pt(Me)(Dmso)][PF6]), the Heterobimetallic Derivative Obtained in the Reaction Between the Organometallic Compound [Pt(Pbi)(Me)(Dmso)], Pbi=2-(2'-Pyridil)Benzimidazole (Compound 3) and the Gold(I) Compound [Au(PH3P)][PF6], PDB code: 5e5f:

Gold binding site 1 out of 1 in 5e5f

Go back to Gold Binding Sites List in 5e5f
Gold binding site 1 out of 1 in the X-Ray Structure of the Complex Between Rnase A and Compound 4-PF6 ([(PPH3)Au(Mi-Pbi)Pt(Me)(Dmso)][PF6]), the Heterobimetallic Derivative Obtained in the Reaction Between the Organometallic Compound [Pt(Pbi)(Me)(Dmso)], Pbi=2-(2'-Pyridil)Benzimidazole (Compound 3) and the Gold(I) Compound [Au(PH3P)][PF6]


Mono view


Stereo pair view

A full contact list of Gold with other atoms in the Au binding site number 1 of X-Ray Structure of the Complex Between Rnase A and Compound 4-PF6 ([(PPH3)Au(Mi-Pbi)Pt(Me)(Dmso)][PF6]), the Heterobimetallic Derivative Obtained in the Reaction Between the Organometallic Compound [Pt(Pbi)(Me)(Dmso)], Pbi=2-(2'-Pyridil)Benzimidazole (Compound 3) and the Gold(I) Compound [Au(PH3P)][PF6] within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Au201

b:61.6
occ:0.30
NE2 A:HIS105 2.2 25.9 1.0
O A:HOH410 2.4 34.4 0.7
CE1 A:HIS105 2.7 24.6 1.0
O A:HOH400 2.7 31.3 0.7
O A:HOH409 2.9 35.3 0.7
CD2 A:HIS105 3.3 24.1 1.0
O B:HOH260 3.5 44.1 0.7
ND1 A:HIS105 3.8 27.4 1.0
O A:HOH342 3.8 45.1 1.0
CG A:HIS105 4.1 22.5 1.0
O A:HOH406 4.1 37.0 1.0
O A:HOH412 4.3 39.1 1.0
O A:TYR76 4.7 25.1 1.0
O A:HOH360 4.8 30.2 1.0
CG2 A:THR78 5.0 23.6 1.0

Reference:

M.Serratrice, L.Maiore, A.Zucca, S.Stoccoro, I.Landini, E.Mini, L.Massai, G.Ferraro, A.Merlino, L.Messori, M.A.Cinellu. Cytotoxic Properties of A New Organometallic Platinum(II) Complex and Its Gold(I) Heterobimetallic Derivatives. Dalton Trans V. 45 579 2015.
ISSN: ESSN 1477-9234
PubMed: 26609781
DOI: 10.1039/C5DT02714D
Page generated: Sat Dec 12 01:54:15 2020

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