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Gold in PDB 4oot: X-Ray Structure of the Protein-Gold Adduct Formed Upon Reaction of Aubipic with Hen Egg White Lysozyme

Enzymatic activity of X-Ray Structure of the Protein-Gold Adduct Formed Upon Reaction of Aubipic with Hen Egg White Lysozyme

All present enzymatic activity of X-Ray Structure of the Protein-Gold Adduct Formed Upon Reaction of Aubipic with Hen Egg White Lysozyme:
3.2.1.17;

Protein crystallography data

The structure of X-Ray Structure of the Protein-Gold Adduct Formed Upon Reaction of Aubipic with Hen Egg White Lysozyme, PDB code: 4oot was solved by A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.55 / 1.80
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 76.979, 76.979, 38.089, 90.00, 90.00, 90.00
R / Rfree (%) 18.1 / 24.4

Gold Binding Sites:

The binding sites of Gold atom in the X-Ray Structure of the Protein-Gold Adduct Formed Upon Reaction of Aubipic with Hen Egg White Lysozyme (pdb code 4oot). This binding sites where shown within 5.0 Angstroms radius around Gold atom.
In total only one binding site of Gold was determined in the X-Ray Structure of the Protein-Gold Adduct Formed Upon Reaction of Aubipic with Hen Egg White Lysozyme, PDB code: 4oot:

Gold binding site 1 out of 1 in 4oot

Go back to Gold Binding Sites List in 4oot
Gold binding site 1 out of 1 in the X-Ray Structure of the Protein-Gold Adduct Formed Upon Reaction of Aubipic with Hen Egg White Lysozyme


Mono view


Stereo pair view

A full contact list of Gold with other atoms in the Au binding site number 1 of X-Ray Structure of the Protein-Gold Adduct Formed Upon Reaction of Aubipic with Hen Egg White Lysozyme within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Au201

b:44.9
occ:0.60
O A:HOH301 2.3 20.9 0.6
NE2 A:GLN121 2.4 34.1 0.6
OE1 A:GLN121 2.6 37.5 0.6
CD A:GLN121 2.8 35.6 0.6
NE2 A:GLN121 3.4 34.8 0.4
O A:HOH372 3.5 45.4 1.0
CG A:GLN121 4.3 35.5 0.6
CD A:GLN121 4.5 36.4 0.4
NH1 A:ARG125 4.7 75.9 1.0
CB A:GLN121 4.9 34.1 0.6

Reference:

L.Messori, M.A.Cinellu, A.Merlino. Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(C.). Acs Med Chem Lett V. 5 1110 2014.
PubMed: 25313321
DOI: 10.1021/ML500231B
Page generated: Sat Dec 12 01:54:06 2020

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