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Gold in PDB 4mxf: X-Ray Structure of the Adduct Between Bovine Pancreatic Ribonuclease and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers

Enzymatic activity of X-Ray Structure of the Adduct Between Bovine Pancreatic Ribonuclease and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers

All present enzymatic activity of X-Ray Structure of the Adduct Between Bovine Pancreatic Ribonuclease and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers:
3.1.27.5;

Protein crystallography data

The structure of X-Ray Structure of the Adduct Between Bovine Pancreatic Ribonuclease and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers, PDB code: 4mxf was solved by I.Russo Krauss, A.Vergara, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 23.00 / 2.25
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 99.595, 31.297, 69.027, 90.00, 90.53, 90.00
R / Rfree (%) 18.5 / 26.8

Gold Binding Sites:

The binding sites of Gold atom in the X-Ray Structure of the Adduct Between Bovine Pancreatic Ribonuclease and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers (pdb code 4mxf). This binding sites where shown within 5.0 Angstroms radius around Gold atom.
In total only one binding site of Gold was determined in the X-Ray Structure of the Adduct Between Bovine Pancreatic Ribonuclease and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers, PDB code: 4mxf:

Gold binding site 1 out of 1 in 4mxf

Go back to Gold Binding Sites List in 4mxf
Gold binding site 1 out of 1 in the X-Ray Structure of the Adduct Between Bovine Pancreatic Ribonuclease and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers


Mono view


Stereo pair view

A full contact list of Gold with other atoms in the Au binding site number 1 of X-Ray Structure of the Adduct Between Bovine Pancreatic Ribonuclease and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Au201

b:60.0
occ:0.50
 NE2 A:HIS12 2.3 27.7 1.0
ND1 A:HIS119 2.5 40.2 0.5
CD2 A:HIS12 3.1 26.9 1.0
CE1 A:HIS119 3.1 41.0 0.5
NE2 A:GLN11 3.2 37.4 1.0
CE1 A:HIS12 3.4 29.1 1.0
N A:PHE120 3.6 25.5 1.0
CA A:HIS119 3.6 30.9 0.5
CA A:HIS119 3.6 29.0 0.5
CG A:HIS119 3.7 38.0 0.5
O A:VAL118 4.0 29.8 1.0
C A:HIS119 4.1 28.7 1.0
CB A:HIS119 4.2 33.9 0.5
CG A:HIS12 4.3 27.3 1.0
NE2 A:HIS119 4.3 41.5 0.5
CD A:GLN11 4.4 37.5 1.0
CB A:HIS119 4.4 29.7 0.5
ND1 A:HIS12 4.4 28.5 1.0
CD1 A:PHE8 4.5 22.8 1.0
O A:HOH333 4.5 32.7 0.5
CB A:GLN11 4.5 29.2 1.0
N A:HIS119 4.6 29.8 1.0
ND1 A:HIS119 4.6 31.0 0.5
CB A:PHE120 4.6 25.7 1.0
CD2 A:HIS119 4.6 39.6 0.5
C A:VAL118 4.7 29.2 1.0
CA A:PHE120 4.7 24.5 1.0
NZ A:LYS41 4.8 26.9 1.0
CG A:HIS119 4.9 29.7 0.5

Reference:

L.Messori, F.Scaletti, L.Massai, M.A.Cinellu, I.Russo Krauss, G.Di Martino, A.Vergara, L.Paduano, A.Merlino. Interactions of Gold-Based Drugs with Proteins: Crystal Structure of the Adduct Formed Between Ribonuclease A and A Cytotoxic Gold(III) Compound. Metallomics V. 6 233 2014.
ISSN: ISSN 1756-5901
PubMed: 24287583
DOI: 10.1039/C3MT00265A
Page generated: Sat Dec 12 01:54:06 2020

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