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Gold in PDB 4lfx: X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers

Enzymatic activity of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers

All present enzymatic activity of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers:
3.2.1.17;

Protein crystallography data

The structure of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers, PDB code: 4lfx was solved by A.Vergara, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.88 / 2.10
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 78.269, 78.269, 37.208, 90.00, 90.00, 90.00
R / Rfree (%) 20.4 / 28.1

Other elements in 4lfx:

The structure of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms
Sodium (Na) 1 atom

Gold Binding Sites:

The binding sites of Gold atom in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers (pdb code 4lfx). This binding sites where shown within 5.0 Angstroms radius around Gold atom.
In total only one binding site of Gold was determined in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers, PDB code: 4lfx:

Gold binding site 1 out of 1 in 4lfx

Go back to Gold Binding Sites List in 4lfx
Gold binding site 1 out of 1 in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers


Mono view


Stereo pair view

A full contact list of Gold with other atoms in the Au binding site number 1 of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Au204

b:42.5
occ:0.50
 NE2 A:HIS15 2.3 28.9 1.0
CL A:CL205 2.6 12.0 0.5
CD2 A:HIS15 2.9 28.3 1.0
NH2 A:ARG14 3.0 31.3 1.0
CG1 A:ILE88 3.4 25.8 1.0
OD1 A:ASP87 3.4 30.8 1.0
CE1 A:HIS15 3.5 30.0 1.0
N A:ILE88 3.9 26.6 1.0
OG1 A:THR89 4.0 24.8 1.0
N A:THR89 4.1 24.0 1.0
CZ A:ARG14 4.1 31.5 1.0
CG A:HIS15 4.2 28.3 1.0
CG A:ASP87 4.2 30.7 1.0
CD1 A:ILE88 4.3 24.8 1.0
CB A:ALA11 4.4 25.6 1.0
ND1 A:HIS15 4.4 29.4 1.0
CA A:ILE88 4.4 25.2 1.0
C A:ILE88 4.5 25.3 1.0
CB A:ILE88 4.5 25.1 1.0
NE A:ARG14 4.6 30.8 1.0
O A:ALA11 4.7 24.2 1.0
C A:ASP87 4.7 25.6 1.0
OD2 A:ASP87 4.7 30.2 1.0
CA A:THR89 4.7 23.5 1.0
CA A:ASP87 4.8 27.9 1.0
CA A:ALA11 4.9 25.2 1.0

Reference:

L.Messori, F.Scaletti, L.Massai, M.A.Cinellu, C.Gabbiani, A.Vergara, A.Merlino. The Mode of Action of Anticancer Gold-Based Drugs: A Structural Perspective. Chem.Commun.(Camb.) V. 49 10100 2013.
ISSN: ISSN 1359-7345
PubMed: 24045294
DOI: 10.1039/C3CC46400H
Page generated: Wed Jul 10 14:24:35 2024

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